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Musculo-Skeletal (3/3)
Ohio State University - Columbus, OH
College of Veterinary Medicine
Bertone, A. L.
INFLUENCE OF STEROID SUPPRESSION ON ARTICULAR CARTILAGE HEALING AND JOINT FUNCTION IN STRESSED EQUINE TARSOCRURAL JOINTS.
Abstract: The purpose of this study is to evaluate joint function and healing of full thickness cartilage defects in exercising equine athletes in the face of intra-articular corticosteroids or a balanced electrolyte solution. Twelve horses will be used in this study. Six will be euthanized on day 90 and 6 on day 180 and the equality of repair tissue and adjacent articular cartilage evaluated grossly, histochemically and histomorphometrically.
Ohio State University - Columbus, OH
College of Veterinary Medicine
Reed, S. M.
ACCURACY OF SURVEY RADIOGRAPHS FOR THE IDENTIFICATION OF HORSES WITH CERVICAL STENOTIC MYELOPATHY.
Abstract: The objective of this study will be to determine the ability of survey radiographs to identify cervical stenotic myelopathy affected horses based on minimum sagittal diameter measurements from survey radiographs will be determined, and a method to eliminate this factor will be investigated. The incidence and severity of vertebral body and articular facet abnormalities in the non-ataxic horse population and CSM affected horses, will be documented to determine the significance of these lesions in the pathogenesis of disease.
Ohio State University - Columbus, OH
College of Veterinary Medicine
Schneider, R.
EFFECTS OF EXERCISE ON EQUINE ARTICULAR CARTILAGE REPAIR IN JOINTS MEDICATED WITH POLYSULFATED GLYCOSAMINOGLYCAN OR SODIUM HYALURONATE.
Abstract: Little is known about equine cartilage healing during exercise. The effect of PSGAG and SH on healing of equine articular cartilage was investigated in 12 exercised horses. Results of this study indicated that PSGAG and SH had no beneficial effect on clinical parameters, the gross appearance, or the microscopic appearance of defects when compared to saline controls. Some evidence from this study suggests that intra-articular PSGAG may have a detri- mental effect on the healing of articular cartilage. We feel that these medi-
Ohio State University - Columbus, OH
College of Veterinary Medicine
Schneider, R.
FUSION OF THE DISTAL INTERTARSAL AND TARSOMETATARSAL JOINTS IN THE HORSE USING INTRA-ARTICULAR SODIUM MONOIODOACETATE.
Abstract: This project investigated a non-surgical technique for fusing the distal hock joints in clinically normal horses. Sodium monoiodoacetate (MIA) is a chemical which selectively destroys cartilage, but has little effect on surrounding soft tissues. Six normal horses received three intra-articular injections of MIA in two distal hock joints. Following injections of MIA, all horses underwent a gradually increasing exercise program over a 24 week period. All treated joints showed radiographic and microscopic evidence of joint fusion.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Beard, W.L.; Bramlage, L.R.; Schneider, R.K.; Embertson, R.M.
POSTOPERATIVE RACING PERFORMANCE IN UNRACED STANDARDBRED AND THOROUGHBRED HORSES WITH OSTEOCHONDROSIS OF THE TIBIOTARSAL JOINT: 109 CASES.
Abstract: Sixty-four Thoroughbred and 45 Standardbred horses has osteochondrosis dissecans fragments of the tibiotarsal joint removed by arthroscopy before two years of age. They were compared to their siblings for the number of starts and dollars. Twenty-two percent of Standardbreds raced as 2-year-olds and 43% as 3-year olds, compared to 42% and 50% of the siblings. Forty-three percent of operated Thoroughbreds raced as 2-year-olds and 78% as 3-year-olds compared to 48% and 73% in the sibling group. (more on next page)
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A.
DETERMINATION OF SYNOVIAL MEMBRANE BLOOD FLOW IN EQUINE JOINTS USING COLORED MICROSPHERES.
Abstract: The objectives of this study were to use a colored microsphere technique to measure regional synovial membrane blood flow in normal equine carpi and fetlock joints, and to determine the effects of increased intra-articular pressure on synovial blood flow. Colored microspheres provided a useful method for determination of regional synovial membrane blood flow in a given joint provided systemic circulatory parameters remained stable. This method was useful to demonstrate the significant alterations in blood flow
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A. L.; Carter, B. G.; Weisbrode, S.
INFLUENCE OF STEROID SUPPRESSION ON ARTICULAR CARTILAGE HEALING AND JOINT FUNCTION IN STRESSED EQUINE TARSOCRURAL JOINTS.
Abstract: This study evaluated joint function and healing of full thickness cartilage defects in exercised horses following intra-articular (IA) methylprednisolone acetate (MPA) and contralateral IA balanced electrolyte solution (BES). Twelve horses (24 tarsocrural joints) were used in this study. A single dose of MPA slows maturation of repair tissue short-term, but does not effect quality long-term.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A. L.; Palmer, J. L.
SYNOVIAL FLUID CYTOKINES, EICOSANOIDS, AND GLYCOSAMINOGLYCANS AS MARKERS OF INFLAMMATORY JOINT DISEASE.
Abstract: Joint injury and disease represent the single largest cause of loss of performance in the equine industry. The majority of musculoskeletal injuries primarily or secondarily involve the joint. Inflammation of the synovial tissue lining the joint capsule is a factor common to many joint related problems. The objective of this prospective study is to more thoroughly define the physical and chemical properties of synovial fluid associated with clinical stages of joint inflammation. Synovial fluid samples are currently being collected.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A. L.; Palmer, J. L.; Litsky, A.
MECHANICAL CHARACTERISTICS OF THE EQUINE THIRD CARPAL BONE.
Abstract: The equine carpal joint is the most injured joint in the equine athlete and problems of the equine carpus have been repeatedly reported in the literature. Although the mechanical behavior of the 3rd carpal subchondral bone has been studied, there have been no reports on the mechanical characteristics of the articular cartilage on the surface of the 3rd carpal bone.Since it is likely that this bone receives different applied loads dependent on the posture of the limb and location of the bone, it is also reasonable to expect that there
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A. L.; Palmer, J. L.; Malemud, C.; Litsky, A.
CORRELATIVE BIOMECHANICAL/BIOCHEMICAL PROPERTIES OF ARTICULAR CARTILAGE AND SYNOVIA IN EXERCISED AND NONEXERCISED JOINTS.
Abstract: The purpose of this study is to detemine the biomechanical and bio- chemical properties of 12 sites on the proximal, articular, surface of the equine third carpal bone in six exercised and 6 nonexercised Standardbred horses. The new information provided by this study includes: 1) documentation of the variability in biomechanical and biochemical properties of articular cartilage in the preselected sites for future studies on the mechanism of synovial manipulation on articular cartilage characteristics; 2) a correlation
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A. L.; Palmer, J. L.; Stevenson, S. L.
ACUTE EFFECTS OF SYNOVECTOMY ON ARTICULAR CARTILAGE AND SYNOVIA.
Abstract: The aim of this research plan is to define the effects associated with an extensive synovectomy using the horse as an appropriate model. We plan to study, in detail, the effects of synovectomy on the articular cartilage, the synovial tissue remaining in the joint and the synovial fluid, in carpal joints free of any pre-existing disease process and in carpal joints in which an exper- imentally-induced synovitis has been created.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A. L.; Palmer, J. L.; Stevenson, S. L.; Weisbrode, S.; Litsky, A.
ACUTE EFFECTS OF SUBTOTAL SYNOVECTOMY ON THE PHYSICAL AND BIOCHEMICAL PROPERTIES OF ARTICULAR CARTILAGE AND SYNOVIA IN HORSES.
Abstract: The aim of this research plan is to define the effects associated with an extensive synovectomy. We plan to study, in detail, the effects of synovectomy on the articular cartilage, the synovial tissue remaining in the in the joint and the synovial fluid, in carpal joints free of any pre-existing disease process and in carpal joints in which an experimentally-induced synovi- tis has been created. Acute effects will be studied on the articular cartilage and synovia since early release of inflammatory mediators from the synovium is
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A.; Carter B.; Weisbrode, S.; Bailey, M.; Andrews, J. Palmer, J.
INFLUENCE OF STEROID SUPPRESSION ON THE HEALING OF MORE AND LESS WEIGHTBEARING OSTEOCHONDRAL DEFECTS IN EQUINE TARSOCRURAL JOINTS.
Abstract: This study evaluated joint function and healing of full-thickness osteochondral defects in boxstall rested horses following intra-articular (IA) methylprednisolone acetate (MPA) and contralateral IA balanced electrolyte solution (BES).
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A.; Rocchiari, R.; Palmer, J.; Weisbrode, S.
THE EFFECTS OF RUTHENIUM HEXAMINE TETRACHLORIDE, FORMALIN AND GLUTARALDEHYDE FIXATION, AND ACID AND CHELATION DECALCIFICATION ON LIGHT MICRO- SCOPIC VISUALIZATION OF PROTEOGLYCANS IN THE ARTICULAR CARTILAGE ON THE HORSE.
Abstract: Proteoglycans (PG's) may be lost from the tissue during fixing and processing. Ruthenium hexamine tetrachloride (RHT) has proved to be useful in preserving PG's for electron microscopy. The objective of this study is to study the effects of ruthenium hexamine tetrachloride, formalin and glutaralkehyde fixation, and acid and chelation decalcification on light microscopic visualiza- tion of proteoglycans in the articular cartilage on the horse.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A.L.; Holcombe, S.L.
SOFT TISSUE INJURIES OF THE EQUINE STIFLE.
Abstract: Soft tissue injuries of the femoropatellar and medial femorotibial joints are difficult to diagnose and may require diagnostic arthroscopy. The purpose of this study was to describe the normal anatomy of the soft tissue of the femoropatellar and femorotibial joint pouches and new arthroscopic approaches to the caudal femorotibial joint.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Bertone, A.L.; Plamer, J.L.; Jones, J.
SYNOVIAL FLUID INFLAMMATORY MEDIATORS AS MARKERS OF EQUINE SYNOVITIS.
Abstract: Recent advances in techniques can detect low levels of cytokines and eicosanois in synovial fluid and may provide a more sensitive indicator of joint inflammation and possibly cartilage damage. The objective of this pros- pective study was to define the chemical properties of synovial fluid associated with clinical stages of joint inflammation.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Carter, B.G.; Bertone, A.L.; Weisbrode, S.E.; Bailey, M. Andrews, J. Palmer, J. L.
INFLUENCE OF STEROID SUPPRESSION ON OSTEOCHONDRAL HEALING IN STRESSED EQUINE TARSOCRURAL JOINTS.
Abstract: This study evaluated joint function and healing of full thickness cartilage defects in exercised horses following intra-articular (IA) methylprednisolone acetate (MPA) and contralateral IA balanced electrolyte solution (BES).
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Hardy, J.; Bertone, A.; Malemud, C.
EFFECT OF BACTERIAL INFECTION ON ARTICULAR CARTILAGE METABOLISM IN VITRO.
Abstract: The purpose of this study was to develop an in vitro model for the study of septic arthritis and to investigate the influence of the synovial membrane on articular cartilage metabolism in septic arthritis. Results show that infected equine synovial membrane releases mediators that significantly decrease cartilage metabolism and induce cartilage degradation, even as early a 6 hours after infection. Furthermore, these mediators trigger significant alterations in cartilage metabolism even when infection is no longer present.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Hardy, J.; Bertone, A.; Malemud, C.
EFFECT OF BACTERIAL INFECTION ON HYALURONATE SYNTHESIS BY THE EQUINE SYNOVIAL MEMBRANE IN VITRO.
Abstract: The purpose of this study was to investigate the effect of bacterial infection on synovial membrane hyaluronate synthesis to determine if early hyaluronate replacement may enhance early return of joint health. From this study,we can conclude that successful eradication of the bacterial inoculum is insufficient for restoration of articular health following joint infection. Additional treatment modalities aiming at inhibition of mediators produced by the synovial membrane in infection would ameliorate the response to therapy
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Holcombe, S.; Bertone, A.; Biller, D.
MAGNETIC RESONANCE IMAGING OF THE EQUINE STIFLE.
Abstract: The etiology of stifle lameness can be difficult to identify in the horse. Current, non-surgical methods of evaluating the equine stifle include radiography and utrasonography. Neither of these modalities permits accurate evaluation of the articular cartilage or soft tissue structures within the joint. Magnetic resonance imaging is a useful diagnostic tool in human medicine for evaluating the genu. The purpose of this study was to define normal gross anatomic magnetic resonance images of the stifle joint.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Holcombe; Schneider; Bramlage; Gabel; Bertone; Beard
NONCOMMINUTED SAGITTAL FRACTURES OF THE PROXIMAL PHALANX IN 59 RACE HORSES TREATED WITH LAG SCREW FIXATION, 1973-1991.
Abstract: The medical records of 62 horses with noncomminuted mid-sagittal proximal phalanx fractures repaired with lag screw fixation from 1973 to 1991 were reviewed. There was no significant difference in time from fracture occurrence to fracture repair for horses that returned to racing compared to horses that did not race for any of the fracture groups.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Izumisawa,Y.; Tangkawattana,P.; Chang,Y.; Masty,J. Hardy,J.; Bertone,A.; Yamaguchi,M.
SYNOVIAL VILLI: DISTINCT STRUCTURAL ARRANGEMENT.
Abstract: Not Reported
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Palmer, J.; Bertone, A.; Mansour, J.; Carter, B.; Papay, R.; Malemud, C.
SITE SPECIFIC BIOCHEMICAL CHARACTERISTICS OF THIRD CARPAL ARTICULAR CARTILAGE IN EXERCISED VERSUS NON-EXERCISED HORSES: COMPARISON WITH INDENTATION PROPERTIES.
Abstract: The objective of this study was to determine and compare the extracellular matrix characteristics of the contralateral limb of these same areas on the equine third carpal bone in exercised and non-exercised horses.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Palmer, J.; Bertone, A.; Papay, R.; Malemud, C.
EFFECT OF EXPERIMENTALLY-INDUCED ACUTE SYNOVITIS ON ARTICULAR CARTILAGE PROTEOGLYCAN SYNTHESIS AND COMPOSITION.
Abstract: The objective of this study was to more fully characterize the effect of acute synovitis on the extracellular matrix composition and synovial fluid using an experimentally-induced model of inflammation.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Palmer, J.L.; Bertone, A. L.; McClain, H.
QUANTIFICATION OF SULPHATED GLYCOSAMINOGLYCANS IN EQUINE SYNOVIAL FLUID AS A MARKER OF INFLAMMATORY JOINT DISEASE.
Abstract: NOT REPORTED
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Palmer, J.L.; Bertone, A.L.; Bailey M.; Scheck, S.; Ehreseman, M.
EVALUATION OF TECHNETIUM 99m-LABELED NON-SPECIFIC IMMUNOGLOBULIN FOR THE DETECTION OF EQUINE ACUTE INFLAMMATION.
Abstract: This study evaluates the use of non-specific Tc-99m-IgG isotype in an equine model of acute synovitis. Eight horses with radiographically normal carpi were studied. Results showed an increased tendency towards accumulation of nonspecific Tc-99m-IgG possibly suggests its future use as a diagnostic tool in the detection of acute focal inflammation.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Palmer, J.L.; Bertone, A.L.; Litsky, A.S.
CONTACT AREA AND PRESSURE DISTRIBUTION CHANGES OF THE EQUINE THIRD CARPAL BONE DURING LOADING.
Abstract: Trauma and subsequent degenerative disease of the carpus in racing horses is a frequent occurrence. The most common site of injury is the proximal site of the third carpal bone due to the high loads placed upon it during the weight-bearing phases of the stride during galloping. The objective of this study was to define the changes that occur during alterations in the load bearing phase of the carpus in terms of contact area and pressure distribution.
Ohio State University - Columbus, OH 43210
College of Veterinary Medicine
Palmer, J.L.; Bertron, A.L.; Mansour, J.
SITE SPECIFIC INDENTATION CHARACTERISTICS OF THIRD CARPAL ARTICULAR CARTILAGE IN EXERCISED VERSUS NON-EXERCISED HORSES.
Abstract: The objective of this study was to determine and compare the indentation characteristics on the equine third carpal bone in exercised and non-exercised horses. Site and exercise differences in the indentation characteristics of the equine third carpal bone accurately reflect the defined mechanical and functional behavior. Cartilage of low-load contant weight-bearing areas demonstrated less cartilaginous compressive capability and an increase in aggregate modulus than cartilage of high-load intermittent weight-bearing areas.
Ohio State University - Columbus, OH 43210
Department of Veterinary Anatomy
Masty, J.; Stradley, R.
THE GASTROINTESTINAL PEPTIDE SUBSTANCE P: A POTENTIAL LINK IN THE TRIGGERING MECHANISM OF EQUINE ALIMENTARY LAMINITIS.
Abstract: The neuropeptide substance P (SP) has been shown to be not only one of the most potent vasodilators in the body but also one of the most powerful stimulants for the contraction of intestinal smooth muscle. Through immunohistochemical techniques, substance P has been localized in all layers of the equine intestinal wall in neurons and their processes. The normal effect of substance P on the layers of intestinal muscle has been determined and will be compared with intestinal muscle from animals in the laminites group.
Ohio State University - Columbus, OH 43210
Dept. of Clinical Sciences
Bramlage, L. R.
CLINICAL EVALUATION OF SUPERIOR CHECK LIGAMENT.
Abstract: Desmotomy as a treatment for tendonitis of the superficial digital flexor. Clinical trial on 51 racing Thoroughbreds. Surgeries have been done and 2 years racing completed.
Ohio State University - Columbus, OH 43210
Dept. of Vet Clinical Sciences
Bramlage, L. R.
EFFECTS OF PERCUTANEOUS TENDON SPLITTING IN ACUTE EQUINE TENDINITIS.
Abstract: Acute tendinitis is a common cause of lameness in athletic horses. Clinical reports have indicated an improved return to function with tendon splitting. The effects of surgical splitting on the acute inflammatory phase of tendinitis have not been investigated. This study proposes such an investigation.
Ohio State University - Columbus, Ohio 43210
College of Veterinary Medicine
Masty, J.; Stradley, R. P.
OPIOID MESSANGER FUNCTION IN NEUROMODULATION OF EQUINE INTESTINAL MOTILITY: ROLE OF MET-ENKEPHALIN IN THE CARBOHYDRATE INDUCED LAMINITIS MODEL.
Abstract: The goals are: 1) To determine the immunohistochemical distribution and synaptic associations of the opioid neuropeptide (ME) in the intramural ganglia of the normal equine intestine and compare it with the distribution seen in ponies with laminitis induced by carbohydrate overload; 2) To determine the in vitro effect of ME on normal equine intestinal smooth muscle contraction in the presence and absence of the narcotic antagonist naloxone; 3) To determine the in vitro effect of ME on intestinal smooth muscle contraction with naloxone.
Ohio State University - Columbus, Ohio 43210
College of Veterinary Medicine
Schneider, R.
RETROSPECTIVE ANALYSIS OF 317 EQUINE RADIOCARPAL BONE FRACTURES.
Abstract: Carpal chip fractures are a common injury in racehorses, and represent a significant economic loss for the racing industry. The objectives of this study are: 1) obtain case records, radiographic records and surgical descriptions for all horses diagnosed with radiocarpal bone fractures at OSU between 1980-89, 2) extract information from these records related to fracture occurrence and management, 3) obtain pre and post-fracture racing performance information 4) determine factors affect post-fracture racing performance.
Oklahoma State University
College of Veterinary Medicine
Collier; Burba
IN VIVO STUDY OF UPTAKE AND DISTRIBUTION OF INTRAMUSCULAR TRITIUM-LABELLED PSGAG (ADEQUAN) IN ARTICULAR CARTILAGE AND IN A OSTEOCHONDRAL IN THE HORSE.
Abstract: Degenerative joint disease is a common cause of joint pain and impaired function, including lameness, in horses. The investigators studied the uptake and distribution 3H-PSGAG (Adequan, a polysulfated glycosaminoglycan) into cartilage and cartilage defects after intramuscular injection. This kinetic study generated knowledge on the effect of polysulfated glycosaminoglycan on the production of hyaluronate by cells in the synovial membrane of the intercarpal joint & changes in joint tissue & articular repair.
Oklahoma State University
College of Veterinary Medicine
Jann; Stein; Good
STRENGTH CHARACTERISTICS AND FAILURE MODES OF LOCKING-LOOP AND THREE-LOOP PULLEY SUTURE PATTERNS IN EQUINE TENDONS.
Abstract: The purpose of this study is to determine the (1) maximal loads to failure, (2) gaps a maximum load, (3) loads to create a 2 mm gap (4) loads to create a 10 mm gap, and (5) failure modes of the locking loop and three-loop pulley suture patterns at a rapid loading rate using equine tendons.
Oklahoma State University
College of Veterinary Medicine
Stein; Short
IN VITRO AND IN VIVO ASSESSMENT OF TENDON HEALING POTENTIAL.
Abstract: This work should establish safe method of utilizing growth factors and extracellular matrix components to treat crippling tendon and ligament injuries. By creating wound care applications for these products, demand for commercial suppliers to produce these products will be increased. Tissue culture technology will be used to examine age-related changes in tendon healing potential.
Oklahoma State University - Stillwater, OK 74078
College of Veterinary Medicine
Collier, M.; Pallin, G.; Johnson, L.
LONG TERM EFFECTS OF HOLMIUM:YAG LASER RADIATION ON CARTILAGE METABOLISM, HEALING. BIOCHEMICAL PROPERTIES OF REPAIR TISSUE AND SUBCHONDRAL BONE HEALING IN A WEIGHT BEARING CHRONIC LESION MODEL.
Abstract: Objectives of this research are to (1) histologically compare perilesional cartilage, lesional repair tissue and subchondral bone healing in controls and treated following treatment of chronic (10 week) full thickness cartilage lesions and perilesional cartilage with a selected level of Ho:YAG laser energy and six months of continuous active weight bearing, and (2) to perform biochemical evaluation of lesional reparative tissue and perilesional cartilage six months following exposure to laser energy.
Oklahoma State University - Stillwater, OK 74078
College of Veterinary Medicine
Collier, M.A.; Ciacciarelli, T.; Walls, R.C.
EFFICACY OF IM PSGAG IN THE TREATMENT OF NAVICULAR DISEASE: A CLINICAL FIELD TRIAL.
Abstract: Determine efficacy of PSGAG IM in the treatment of clinical navicular disease and evaluate value of nuclear scintigraphy in the diagnosis of this condition and its value in the the evaluation of PSGAG effectiveness as a treatment for navicular disease. Project is being conducted as a double blind clinical field trial and as a pivotal efficacy study.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Clark, D.M.; White, G.; Walls, R.
THE DISTRIBUTION OF RAIOLABELED PSGAG IN CANINE SYNOVIAL FLUID OVER A 72 HOUR PERIOD AND IN ARTICULAR CARTILAGE AT 72 HOURS AFTER INTRAMUSCULAR INJECTION OF 2MG 3HPSGAG PER POUND OF BODY WEIGHT.
Abstract: NOT REPORTED.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Gaylord, E.K.; Petalino, J.
CLINICAL EVALUATION OF SMB FOR TB. TRAINING AND RACING PROTECTION AND SUPPORT.
Abstract: NOT REPORTED. Analysis in progress.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Haugland, L.M.; Johnson, L; DeBault, L.; Walls,R.
REPARATIVE AND DEGENERATIVE CHANGES IN ARTICULAR CARTILAGE DEFECTS IN THE HORSE DURING THE EARLY POST-OPERATIVE PERIOD. (CLOT-1).
Abstract: NOT REPORTED.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Pullin, J.G.
DYNAMIC INTRA-ARTICULAR PRESSURE AND COMPLIANCE OF SURGICAL INSTRUMENTATION PROTOCOLS FOR ARTHROSCOPY USING INTELJET FMS IN AN EQUINE MODEL (CAMINO I).
Abstract: NOT REPORTED. Data collection in progress through 1996.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Pullin, J.G.
DYNAMIC MORMAL INTRA-ARTICULAR PRESSURES AND COMPLIANCE DURING C.P.M. IN THE EQUINE RADIOCARPAL INTERCARPAL, METACARPOPHALANGEAL, FEMOROPATELLAR AND TIBIOTARSAL JOINTS (CAMINO II).
Abstract: NOT REPORTED. Data collection in progress through 1995.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Pullin, J.G.; Johnson, L.
LEGG: PERTHE DISEASE: EQUINE MODEL STUDYING EPIPHYSEAL BONE GRAFTING REPAIR PROCEDURE (HO: CART I-LPD).
Abstract: NOT REPORTED. Surgical procedure complete, tissue collection planned spring 1995.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Pullin, J.G.; Johnson, L.; Smith, L.; DeBault,L.
HO: YAG LASER SHOULDER JOINT CAPSULOPLASTY (LACS): IN VIVO STUDY IN A GREYHOUND MODEL (HO: CART-I-SHOULDER).
Abstract: NOT REPORTED. Surgical procedures completed & tissues analyzed.
Oklahoma State University - Stillwater, OK 74078-0107
BVMTH
Collier, M.A.; Pullin, J.G.; Stephens, D.
QUANTITATIVE ASSESSMENT OF SMX ORTHOPAEDIC EQUINE SADDLE PAD USING FORCE SENSING ARRAY (FSA) COMPUTER ANALYSIS SYSTEM.
Abstract: NOT REPORTED. Data collection to begin late 1994.
Oklahoma State University-Stillwater, OK 74078
College of Veterinary Medicine
Jann, H.
MONOFILAMENT POLYGLYCONATE SUTURE (MAXON) IN FULL-THICKNESS EQUINE SUPERFICIAL FLEXOR TENORRHAPHY.
Abstract: NOT REPORTED
Oregon State University - Corvallis, OR 97331-4802
College of Veterinary Medicine
Blythe, L.; Pearson, E.; Gerros, T.
EQUINE STRINGHALT AND FALSE DANDELION (HYPOCHOERIS RADICATE).
Abstract: A pilot study was undertaken to determine if a diet of 50% (dried weight) of false dandelion (Hypochoeris radicate) would cause clinical signs of stringhalt. Two adult horses were fed 24 and 29 days respectfully and monitored for signs of toxicity. At the end of the trial period, no abnormalities had been detected. Both horses were clinically normal 2 months post cessation of feeding. Some other factors may be involved in this seasonal disease that has been only epidemiologically associated with false dandelion.
Pennsylvania, University of - Kennett Square, PA 19348
New Bolton Center - School of Vet Medicine
Nunamaker, D.
EXTERNAL SKELETAL FIXATION IN THE HORSE: DEVELOPMENT OF A NEW DEVICE FOR IMMEDIATE FULL WEIGHTBEARING THAT MINIMIZES PIN/BONE STRESSES.
Abstract: To optimize the new external skeletal fixation devise by in vitro mechanical testing using equine third metacarpal bones and components of the new device; test the device in vivo in three experimental horses to determine efficacy and safety of the device as a full weightbearing device; and, start a prospective clinical trial using this new device.
Pennsylvania, University of - Kennett Square, PA 19348
School of Vet Medicine - New Bolton Center
Richardson, Dean W.
THE BIOCHEMISTRY AND MORPHOLOGY OF EQUINE ARTICULAR CARTILAGE IN DEGENERATIVE JOINT DISEASE AND THEIR RELATIONSHIP TO SUBCHONDRAL BONE STIFFNESS.
Abstract: The long term objective of this study is to gain a better under- standing of the process of degenerative joint disease, develop a model of progressive cartilage damage that stimulates the naturally occurring physical process, and to use the model to analyze the events that result in disruption of articular cartilage and clinical joint disease.
Pennsylvania, University of - Kennett Square, PA 19348-1692
Dept. of Clinical Studies - New Bolton Center
Boston, Ray
THE ROLE OF TRAINING ON THE INCIDENCE OF BUCKED SHINS IN THOROUGHBRED RACEHORSES.
Abstract: We propose to examine the incidence of bucked shins in two groups of racehorses observed over two years: group A, trained according to our program, and group B trained in some other "Classical" way. Using statistical analysis methods we will determine the influence of different training regimens on the incidence of bucked shins. Preliminary studies suggest that a simple change in training regimes will greatly reduce the incidence of bucked shins in training Thoroughbreds.
Pennsylvania, University of - Kennett Square, PA 19348-1692
New Bolton Center - School of Veterinary Medicine
Richardson, D.
GENE EXPRESSION OF MATRIX MOLECULES IN EQUINE CARTILAGE.
Abstract: The study of gene expression of matrix molecules in equine cartilage. This involves both the cloning of specific equine genes, as well as assessing gene expression in response to cytokines and other factors.
Pennsylvania, University of - Kennett Square,PA 19348
New Bolton Center - School of Vet Medicine
Beech, J.; Fletcher, J. E.; Brown, R. H.
STUDIES ON HYPERKALEMIC PERIODIC PARAYLSIS: DNA ANALYSIS, PHYSIOLOGIC/BIOCHEMICAL STUDIES ON MUSCLE TO CHARACTERIZE DEFECT(S); EVALUATION OF PHENYTOIN'S EFFECTS AND EFFICACY FOR PROPHYLAXIS.
Abstract: Objectives are: 1) to determine whether DNA from affected horses differs from normal horses, specifically with regard to presence of a sodium channel defect as is reported to exist in humans; 2) using both biopsied skeletal muscle and primary muscle cell cultures, determine whether muscle from affected horses has defective sodium channel function and; 3) determine whether and why affected horses' muscle fatty acid metabolism differs from normal horses'; 4) determine how HPP muscle responds to various metabolic and hormonal
Pennsylvania, University of - Kennett Square,PA 19348
New Bolton Center - School of Vet Medicine
Donawick, W.
CERVICAL VERTEBRAL MALFORMATION (WOBBLER SYNDROME) IN THOROUGHBRED HORSES.
Abstract: To determine the incidence, cause(s), treatment, and methods of prevention of Certebral Malformation Syndrome (Wobbler Syndrome) in young Thor- oughbred horses.
Pennsylvania, University of-Kennett Square, PA. 19348
New Bolton Center - Clinical Studies
Nunamaker, D.; Provost, M.; Richardson, D. W.
ORTHOPEDIC RESEARCH.
Abstract: Design and develop a new external skeletal fixator for use in the horse. The design is based on a low cost, high strength device suitable for immediate full weight bearing.
Purdue University - West Lafayette, IN 47907
School of Veterinary Medicine
Ritmeester, A.M.; Adams, S.B.; Blevins, W.E.; Ferguson, D.W.
EFFECT OF CORRECTIVE SHOEING AND CORONARY GROOVING ON DIGITAL VASCULAR PERFUSION IN HORSES WITH CHRONIC LAMINITIS: SEQUENTIAL ANALYSIS USING NUCLEAR SCINTIGRAPHY.
Abstract: Abnormal hoof growth pattern in chronically laminitic horses is associated with alterations in perfusion secondary to displacement of p3. The aim of this project is to determine effects of heart bar shoes and of heart bar shoes and coronary grooving. On digital vascular perfusion, dorsal hoof wall growth rate and p3 rotation. Eleven horses randomly divided into 2 groups were presented for chronic laminitis, treated and re-evaluated every 6 weeks for 6 months. Coronary grooving appears to significantly improve dorsal hoof wall
Purdue University - West Lafayette, IN 47907-1248
School of Veterinary Medicine
Murphey, E.D.; Santschi, E.M.; Papich, M.G.
REGIONAL ANTIMICROBIAL PERFUSION OF THE EQUINE LIMB VIA RETROGRADE INFUSION OF THE DIGITAL VEINS.
Abstract: This study is designed to describe the concentration of amikacin achieved in the soft tissues, bone and synovial fluid in the digit of horses after regional perfusion via the digital vein. The limbs of 4 horses will be perfused; 3 limbs of each horse with Amikacin and salime and one limb with saline only. Samples of joint fluid will be taken during the 30 minutes of perfusion and for 30 minutes after. The horses are then euthanatized and samples of synovial tissue & bone obtained for determination of amikacin concentrations.
Queensland, University of
Dept. of Animal Medicine and Surgery
Pollitt, C.
TO ESTABLISH IF AVA DILATION OCCURS PRIOR TO LAMINITIS.
Abstract: Completion of the project will provide strong evidence that laminitis is preceded by a profound vascular event. This fundamental information will take the AVA hypothesis of laminitis from theory to fact and will provide the logic for new treatment and prevention modalities such as local control of the digital microcirculation as well as manipulation of the gut and uterine microflora. The project will also provide new information on the role of the nerve supply in the pathophysiology of equine laminitis and introduce to the
Queensland, University of - Australia
Dept. of Animal Medicine and Surgery
Pollitt, C.C.
INVESTIGATIONS INTO THE CAUSE AND PREVENTION OF EQUINE LAMINITIS.
Abstract: This project involves a new approach to help target and neutalize the mechanism responsible for the loss of bonding between the pedal bone and the inner hoof wall. The project is developing an innovative approach to study laminitis in the laboratory, featuring cell culture techniques to understand the mechanism for the loss of connection between the inner hoof and the pedal bone. Furthermore, a sensitive blood test will be developed to allow early detection of laminitis, thus increasing the likelihood of effective treatment.
Rutgers University - Cook College, New Brunswick, NJ 08903
Dept. of Animal Sciences
Malinowski, K.; Fagan, J.M.
EFFECT OF STEROIDAL ANTI-INFLAMMATORY DRUG USE ON THE SUSCEPTIBILITY TO INFECTION IN HORSES.
Abstract: Equine athletes are routinely exposed to both physical and phychological stress during competiton, and in addition are liberally given SAID and NSAID. The frequent administration of these drugs in conjunction with stress associated with competition may result in decreased immunocompetence leading to increased susceptibility to infection. Objectives were: to evaluate the effect of acute and chronic glucocorticoid induced immunosuppression on immunocompetence via measurement of the proliferative response of peripheral
Rutgers University - New Brunswick, NJ 08903
Dept. of Animal Science
Black, A.; Shapses, S.; Ralston, S.; Schoknecht, P.
BIOCHEMICAL MARKERS OF BONE TURNOVER TO MONITOR SKELETAL DEVELOPMENT IN FOALS FROM BIRTH TO ONE YEAR.
Abstract: Development orthopedic problems such as soteochondrosis are frequently seen in large, rapidly growing horses. To examine the relationsip between rapid growth, large body size and the development of orthopedic disease in horses, a non-invasive means of evaluating bone turnover is necessary. Serum osteocalcin and urinary pyridinium crosslinks of collagen are sensitive, specific markers of bone formation and resorption respectively. The current study involves monitoring growth parameters,and development of ortopedic disease
Rutgers University - New Brunswick, NJ 08903
Dept. of Animal Science
Ralston, S.; Black, A.; Schoknecht, P.; Shapses, S. McKeever, S.
EFFECTS OF EXERCISE AND HIGH ENERGY DIETS ON SKELETAL DEVELOPMENT IN HORSES.
Abstract: Osteochondrosis (OCD) is common in young horses and results from a disturbance in the growth plate cartilage of long bones. The process by which growth plate cartilage grows and changes into bone is regulated by several hormones including insulin, thyroid hormones, corticosteroids and growth hormone as well as several factors that are produced directly in the cartilage including insulin-like growth factor and transforming growth factor beta. Genetic predisposition, rapid growth rate and large body size, and nutritional and
Saskatchewan, University of
Western College of Veterinary Medicine
Barber; Bailey; Clayton
CLINICAL AND VIDEOGRAPHIC GAIT EVALUATION FOLLOWING LOCAL ANESTHESIA OF THE POSTERIOR DIGITAL NERVE, DISTAL INTERPHALANGEAL JOINT, AND NAVICULAR BURSA IN HORSES WITH NAVICULAR DISEASE SYNDROME.
Abstract: Horses with Navicular Disease Syndrome are being used for this project. All will receive posterior digital nerve blocking and injection of anesthesia into the distal interphalangeal joint and navicular bursa on separate days. The horses will be clinically evaluated after each block and the horse's gait recorded on video. This gait will be analyzed with the Ariel Performance Analysis System. This is to determine gait abnormalities seen in the navicular disease syndrome and to characterize changes seen after each injection.
Saskatchewan, University of
Western College of Veterinary Medicine
Barber; Jones; Leach; Doige
THE HEALING OF EQUINE SYNOVIAL MEMBRANE FOLLOWING MOTORIZED SYNOVIAL RESECTION.
Abstract: A motorized arthroscopically guided synovial resection, and a shame arthroscopic operation were both performed on 18 horses; one procedure to the medial half of each intermediate carpal joint. Six horses were euthanized immediately following surgery as a baseline evaluation of the depth of removal and efficacy of the motorized synovial resection. The horses were evaluated clinically for lameness and joint swelling, and synovial fluid collected pre-operatively and at regular intervals until euthanasia. (next page)
Saskatchewan, University of
Western College of Veterinary Medicine
Barber; Theoret; Clayton; Archer
REPAIR AND FUNCTION OF THE SYNOVIUM AND CLINICAL IMPLICATIONS FOLLOWING "TOTAL" ARTHROSCOPIC SYNOVECTOMY OF THE EQUINE RADIOCARPAL JOINT.
Abstract: Objectives are to evaluate 1) regenerative ability and functional capacity of synovium after "total" synovectomy; 2) effects of total synovectomy on clinical parameters, gait and integrity of joint and cartilage; 3) effect of exercise on healing of the synovial membrane.
Saskatchewan, University of
Western College of Veterinary Medicine
Clayton, H. M.
EFFECT OF WORKING SURFACE ON STRIDE CHARACTERISTICS OF HORSES.
Abstract: Horses were filmed at 200 frames/s moving at a collected trot, an extended trot, a canter and gallop on dirt, woodchip and turf surfaces. Timing, distance and angular measurements of the stride were made, to determine the effect of the different surfaces.
Saskatchewan, University of - Saskatchewan, CA S7N OWO
Dept. of Veterinary Anatomy
Clayton, Hilary M.
CINEMATOGRAPHIC ANALYSIS OF FORELIMB LAMENESS IN HORSES.
Abstract: Lameness is a major cause to economic loss in the equine industry. This study aims, firstly, to characterize the gait asymmetries of horses with different lamenesses and, secondly, to refine the analytic process so that cine or video analysis of gait may eventuall become a practical diagnostic tool. In the first phase of the study, high speed cinematography will be used to record the gait of horses with specific lamenesses moving at a trot. The second phase will commence when multiple lamenesses involving the same area are analysed.
Saskatchewan, University of - Saskatoon, CA S7N 0W0 Western College of Vet Medicine
Equine Health Research Fund
Barber, S.M.
EVALUATION OF BANDAGING IN THE TREATMENT OF LEG WOUNDS.
Abstract: Full thickness skin defects were made on the lateral aspect of distal MT(c)III of all four limbs of four horses. The wounds received one of four treatments: (1) no treatment (NT); (2) nonadhesive bandage; (3) NAB and dermabase cream (NABD); (4) NABD and topical corticosteroids. The wounds were photographed and excessive granulation tissue debrided at 8 day intervals. Analysis: 1) total days to heal for each group; 2) number of debridements needed; 3) cosmetic appearance when healed; 4) height of scar tissue.
Saskatchewan, University of - Saskatoon, CA S7N 0W0 Western College of Vet Medicine
Equine Health Research Fund
Caron, J.P.; Barber, S.M.
THE QUANTITATIVE AND HISTOLOGICAL RESPONSE OF THE EQUINE METACARPAL AND METATARSAL PERIOSTEUM TO CONTROLLED SURGICAL MANIPULATION.
Abstract: Standardardized periosteal flaps were created on the MT(C)III of each leg of four young and four mature horses. Half the periosteal flaps were retained and sutured down while the other half were resected. Some sited were chiselled to remove 1-2 mm of bone prior to replacement or removal of the periosteal flap. Legs were bandaged and the horses confined to a box stall. The legs were radiographed at regular intervals postoperatively. Horses were sacrificed at 30 or 120 days. Histological and microradiography exam performed.
Saskatchewan, University of - Saskatoon, CA S7N 0W0 Western College of Vet Medicine
Equine Health Research Fund
Clayton, H.M.
EFFECT OF HOOF ANGULATION ON STRIDE KINEMATICS OF TROTTING HORSES.
Abstract: High speed cinematography was used to measure stride kinematics in a group of horses with 3 different hoof angle combinations: normal fore and hind hoof angles, normal fore and acute hind hoof angles, and acute fore and hind hoof angles. Horses were filmed at a trot with a minimum of five strides per horse being analyzed for each treatment.
Saskatchewan, University of - Saskatoon, CA S7N 0W0 Western College of Vet Medicine
Equine Health Research Fund
Clayton, H.M.; Townsend, H.G.G.
AN INVESTIGATION OF THE KINEMATICS OF THE EQUINE CERVICAL SPINE.
Abstract: The project was designed to measure precisely the amount of dorsoventral flexion and extension, axial rotation and lateral bending at each cervical vertebral joint from the occiput to the first thoracic vertebra.
Saskatchewan, University of - Saskatoon, CA S7N 0W0 Western College of Vet Medicine
Equine Health Research Fund
Flood, P.E.; Mase, C.; Doige, C.E.; Fretz, P.B.
THE DISTAL RADIAL GROWTH PLATE IN FOALS: NORMAL HISTOLOGY AND HISTOPATHOLOGY OF ANGULAR LIMB DEFORMITIES.
Abstract: The project was designed to compare the reponse of the distal radial growth plate to two surgical techniques: transphyseal bridging, in which staples or screws and wire are used to slow the growth on the convex side of the limb; and periosteal transection and stripping, which allows an increased rate of growth on the concave side.
Saskatchewan, University of - Saskatoon, CA S7N 0W0 Western College of Vet Medicine
Equine Health Research Fund
Hurtig, M.B.; Fretz, P.B.; Doige, C.E.
CORRELATIVE ARTHROSCOPIC - HISTOPATHOLOGIC EVALUATION OF EQUINE ARTICULAR HEALING.
Abstract: Full thickness articular cartilage lesions were made (5mm2) on the third carpal bone and the distal femoral trochlea in adult horses. The lesions were made in one of two locations on the third carpal bone; cranial rim of the radial carpal facet or central aspect of the radial carpal facet, and one of two locations on the lateral trochlea of the distal femur. Horses were destroyed at 1,2,3,6,and 9 months. Lesions were examined grossly and histopathologically. Healing was rated by dye uptake in histological preparation and analyzed.
Saskatchewan, University of - Saskatoon, CA S7N 0W0 Western College of Vet Medicine
Equine Health Research Fund
Leach, D.H.
A STUDY OF THE ULTRASTRUCTURE OF THE VESSELS AND NERVES OF THE NAVICULAR BONE AND ITS ASSOCIATED LIGAMENTS.
Abstract: Interruption of the blood flow to or from the navicular bone has been proposed as a contributing factor in the development of navicular disease. Little is known as to how the nervous system regulates blood flow to the navicular bone. In this study, electron microscopy will be used to describe the ultrastructure of the nerves, arteries and veins of the navicular bone in the normal horse forelimb. Particular attention will be paid to the association between the nerves and vessels as to the pathogenesis of navicular disease.
Saskatchewan, University of - Saskatoon, Canada
Western College of Veterinary Medicine
Clayton, H. M.
THE EFFECT OF GAIT, SPEED AND THE NATURE OF THE TRACK SURFACE ON STRIDE CHARACTERISTICS AND BONE STRAIN IN THE HORSE.
Abstract: NOT REPORTED
Saskatchewan, University of - Saskatoon, Canada S7N 0W0
Equine Health Research Fund
Leach, D. H.
NERVE DISTRIBUTION OF THE EQUINE HOOF WALL DERMAL LAMELLAE.
Abstract: The purposes of this study were 1) to describe the position and anatomy of large caliber (distributing) nerves of the dermal lamellae of the equine hoof wall and 2) to determine if a sympathetic nerve network is associated with the capillary bed of the inner dermal lamellae. Twenty-eight adult horses were sampled for ultrastructural study.
Saskatchewan, University of-Saskatoon, Canada S7N 0W0
Western College of Veterinary Medicine
Fretz; Clark; Haines; Gordon
IL-1 AND TNF ACTIVITY (DETERMINED BY BIOASSAY) IN NORMAL EQUINE SYNOVIAL FLUID AND IN SYNOVIAL FLUID FROM HORSES WITH DEGENERATIVE JOINT DISEASE.
Abstract: The purpose of this project is to try to determine a level of act- ivity as determined by a bioassay for Interleukin-1 and Tumor Necrosis Factor in equine synovial fluid. A bioassay for the determination for Interleukin-1 and Tumor Necrosis Factor was developed for determining activity in equine synovial fluid. Twenty synovial fluid samples taken from joints without degenerative joint disease and twenty synovial fluid samples taken from horses with degenera- tive joint disease will be assayed.
Sydney, University of
Dept of Vet Clinical Studies
Hutchins, D. R.
CLINICAL EVALUATION OF PARTIAL FLOTATION IN THE MANAGEMENT OF SERIOUS LIMB INJURIES IN THE HORSE.
Abstract: The original plan was to treat and follow up about 20 horses over a 2 years period under standard hospital conditions. This original goal has been scaled down. This happened because owners are reluctant to risk an experimental treatment on valuable animals while the insurance status is unclear.
Sydney, University of
Dept. of Vet Clinical Sciences
Rose, R. J.
INVESTIGATION OF THE EFFECTS OF MAXIMAL EXERCISE ON THE MUSCULAR AND CARDIORESPIRATORY SYSTEMS.
Abstract: The idea behind this project was to exercise horses to their maximum capacity on a treadmill and find out what factors were stopping them from going longer or faster.
Tennessee, University of - Knoxville, TN 37901
College of Veterinary Medicine
Adair, H. S.
COMPARISON OF FLEXOR TENDON SUTURE PATTERNS FOR TENDON LACERATIONS (INTERLOCK vs THREE LOOP PULLEY).
Abstract: NOT REPORTED
Tennessee, University of - Knoxville, TN 37901
College of Veterinary Medicine
Adair, H. S.
EFFECT OF INTRA-ARTICULAR DMSO ON SYNOVIAL FLUID PARAMETERS.
Abstract: NOT REPORTED
Tennessee, University of - Knoxville, TN 37901
College of Veterinary Medicine
Shires, M.; Korenek, N.
BIOABSORBABLE STIFLE JOINT IMPLANTS FOR FRACTURE REPAIR AND TENDON STABILIZATION.
Abstract: NOT REPORTED
Tennessee, University of - Knoxville, TN 37901
College of Veterinary Medicine
Wan, P.
FRACTURE STABILIZATION USING ABSORBABLE INTRAMEDULLARY RODS.
Abstract: NOT REPORTED
Texas A & M University, College Station TX 77843
Hood, DM; Amoss, MS; Bratton, GD; Hightower, D; Hunter, JF; Jenkins, WL; Morgan, SJ; Williams, JD; Olivier, A.
EQUINE LAMINITIS.
Abstract: This is a multiyear project which involves investigations of the developmental, acute, and chronic phases of laminitis. Current studies are aimed at defining the basic mechanisms of digital ischemia as well as the digital and systemic responses to the acute episodes of laminitis. In addition, the systemic problems related to laminitis are being investigated.
Texas A&M University - College Station, TX 77843
College of Veterinary Medicine
Hood, D.M.; Grosenbaugh, D.A.; Hayes, T.; Womach, J.; Cleary, K.; Williams, J.D.
METABOLISM AND GROWTH OF THE EQUINE HOOF.
Abstract: This project is designed to define the nutritional requirements and factors which control the metabolism of normal and pathologic equine hoof. Aspects being investigated include defining the keratin genetic polymorphism and phenotype variability, the role of growth factors in regulation of digital laminar epithelium hyperplasia, and the interaction of specific nutritional factors (biotin, methionine, and cystine) in the growth of hoof wall. The role of epidermal growth factor in control of laminar epithelium has been defined.
Texas A&M University - College Station, TX 77843
College of Veterinary Medicine
Hood, D.M.; Gross, D.R.; Martin, J.; Grosenbaugh, D.A.; Williams, J.D.
CONTROL OF THE EQUINE DIGITAL HEMODYNAMICS.
Abstract: This project seeks to define the anatomy and physiologic control of the blood vessels of the equine distal digit. These studies involve a broad range of in vivo and in vitro techniques which are focused on how the blood flow and distribution through the complex vascular bed of the distal digit is controlled. This study is additionally focused on the interactions which occur between the hemodynamics of the distal digit and to the temperature and biomechanical forces to which the foot is subjected during normal activity.
Texas A&M University - College Station, TX 77843
College of Veterinary Medicine
Hood, D.M.; Hogan, H.; Burger, C.; Procopio, G.; Grosenbaugh, D.A.; Williams, J.D.
BIOMECHANICS OF THE EQUINE DISTAL DIGIT.
Abstract: This project seeks to define how the distal digit, i.e., the fetlock down, transmits, absorbs, and dissipates the forces placed on it during normal activity. This project seeks to quantify the events occurring in the distal digit which serve to protect the horse from injury. This project has defined that the distal digit distorts in multiple directions during static loading. The digital distortion appears to transmit little of the imposed force to the anterior coronet.
Texas A&M University - College Station, TX 77843
Dept. of Animal Science - TX Ag Experiment Station
Potter, G. D.
EFFICACY OF EXOGENOUS, RECOMBINANT GROWTH HORMONE ON BONE QUALITY AND MINERAL BALANCE IN THE TWO-YEAR-OLD HORSE IN RACE TRAINING.
Abstract: This project examines the efficacy of administering exogenous, recombinant equine growth hormone (eGH) to enhance bone quality in the two-year-old horse in race training. Horses were dosed with eGH and started training at approximately two-years of age. They were trained in a regimen typical for racing Quarter Horses. Indices of bone remodeling and mineral metabolism were monitored at 28 day intervals for 112 days. Data are being summarized for publication.
Texas A&M University - College Station, TX 77843
Dept. of Animal Science - TX Ag Experiment Station
Potter, G. D.
INFLUENCE OF PRE-TRAINING THE YEARLING HORSE ON CHANGES IN BONE QUALITY IN THE TWO-YEAR-OLD HORSE IN RACE TRAINING.
Abstract: Yearling horses are being pre-trained in a high-speed treadmill beginning at 15 months of age to elicit the bone remodeling process. At 18 months of age, the horse will begin training typical of that for two-year-old Quarter Horses in race training. Indicies of bone remodeling will be monitored at 28-day intervals for 112 days. Pre-trained horses will be compared to controls that do not receive pre-training. Data are being summarized for publication.
Texas A&M University - College Station, TX 77843
Texas Agricultural Experiment Station
Potter, G. D.
MINERAL BALANCE AND THE BONE REMODELING PROCESS IN YOUNG HORSES DURING TRAINING.
Abstract: This is a two-phase project designed to characterize and quantify mineral metabolism during the bone remodeling process when young horses are put into race training. Total mineral intake and excretion will be measured at the initiation of the study and at 28-day intervals for 5 periods. Depending on the outcome of phase I, phase II will be conducted to correct any mineral deficiencies or losses that may occur and to determine the efficacy of those procedures on the bone remodeling process.
Tufts University - N. Grafton, MA 01536
School of Veterinary Medicine
Chandna, V.; Agarwal, R.; Morris, E.; Kirker-Head, C.; O'Callaghan, M.; Kumar, A.
SUBSTANCE P AND PGE2 LEVELS IN NORMAL AND ABNORMAL EQUINE JOINT FLUIDS.
Abstract: A preliminary study was carried out on 22 horses with confirmed joint abnormalities and 22 control horses to correlate the synovial fluid levels of Substance P (SP) and prostaglandin (PGE2) with radiographic changes in joint abnormalities. No significant correlations were found between the levels of these two biochemical components and the degree of joint disorder as rated by radiographic findings.
Tufts University - N. Grafton, MA 01536
School of Veterinary Medicine
Colgan, S.; Kirker-Head, C.A.
APPLICATION OF THE SYNTHESES SELF-TAPPING SCREW SYSTEM IN EQUINE BONE.
Abstract: NOT REPORTED.
Tufts University - N. Grafton, MA 01536
School of Veterinary Medicine
Colgan, S.; Kirker-Head, C.A.
THE APPLICATION OF THE SYNTHES AO/ASIF 4.5mm CANNUALTED SCREW SYSTEM IN EQUINE BONE.
Abstract: NOT REPORTED.
Tufts University - N. Grafton, MA 01536
School of Veterinary Medicine
Sarkar, S. Couetil, L.; Kirker-Head, C.; Kumar, A.
COMPARATIVE ANALYSIS OF CONCENTRATION RELAXATION CYCLE AND FIBER DIVERSITY IN THOROUGHBRED AND NON-THOROUGHBRED EQUINE MUSCLES.
Abstract: The aim of this project is to study the cellular and molecular aspects of equine skeletal muscle fiber diversity, particularly in relation to the problem of functional differences in thoroughbred versus non-thoroughbred muscles. Specifically, we aim to answer the question whether or not differences in speed and force generation in thoroughbred versus non-thoroughbred equine muscles are correlated with altered contractile protein function mediated through variation in isoforms of the appropriate contractile proteins.
Tufts University - North Grafton, MA 01536
School of Veterinary Medicine
Norman, W. H.; Pipers, F. S.; Court, M. H.; Dodman, N. H.
AN INVESTIGATION INTO THE PATHOPHYSIOLOGY OF EQUINE POSTANESTHETIC LAMENESS USING LASER DOPPLER FLOWMETRY.
Abstract: Bilateral determinations of muscle capillary blood flow in the biceps femoris and lateral head of the triceps muscle will be made in 6 healthy conscious horses using laser doppler flowmetry. These determinations will be repeated intermittently in the same group of horses during a 2 hour anesthetic period. Horses will be in lateral recumbency. The preoperative measurements will be compared with those obtained during general anesthesia to define the effects of general anesthesia on muscle blood flow in the horse.
Tufts University School of Vet Med North Grafton, MA 01536
MA Thoroughbred Breeders Association
Fackelman, G.E.; Kraus, A.
A MODEL OF EQUINE DISTAL FLEXOR TENDINITIS.
Abstract: The project involves the initiation of the typical clinical symptoms of EDFT ("bowed tendons") by the creation of a vascular deficit. Following the experimental surgical procedure, the animals are subjected to carefully monitored exercise on the high speed treadmill. Lesions are evaluated by linear measurement, goiometry (of the support of the metacarpophalangeal joint) and forceplate gait analysis. Ultimately the lesions are further analyzed histologically and microangiographically.
Tufts University School of Vet Med North Grafton, MA 01536
TUSUM/Hoechst-Roussel Agricult. Co.
Kirker-Head; Fackelman; Stechel
THE EFFICACY OF PROPERTOPHYLLINE FOR THE TREATMENT OF NAVICULAR DISEASE. A PRELIMINARY STUDY.
Abstract: A study of the efficacy of propertophylline, a hemorrheologic agent, in the treatment of equine navicular disease. A) Assessment of therapeutic drug levels and safety of drug. B) Clinical trial. Drug efficacy assessed using: Clinical evaluation of lameness, radiographic evaluation, forceplate gait analysis, and laboratory blood analysis.
Tufts University-200 Westboro Rd.- North Grafton, MA 01536
Veterinary School
Morris, E.
GENZYME PROTOCOL FOR DETERMINING THE EFFICACY OF INTRA-ARTICULAR HYALURONATE IN THE REDUCTION OF POST-OPERATIVE SYNOVITIS.
Abstract: NOT REPORTED
Tufts University-200 Westboro Rd.- North Grafton, MA 01536
Veterinary School
Morris, E.
OSTEOARTHRITIS AND INTERLEUKIN-1.
Abstract: NOT REPORTED
Tufts University-200 Westboro Rd.- North Grafton, MA 01536
Veterinary School
Morris, E.
OSTEOARTHRITIS: CHARACTERIZATION OF THE PROCESS AND THE ROLE OF INTERLEUKIN-1.
Abstract: NOT REPORTED
Tufts University-200 Westboro Rd.- North Grafton, MA 01536
Veterinary School
Morris, E.
RESIDENCE TIME OF SODIUM HYALURONATE IN THE JOINT FOLLOWING INTRA-ARTICULAR INJECTION.
Abstract: NOT REPORTED
Tufts University-200 Westboro Rd.- North Grafton, MA 01536
Veterinary School
Morris, E.
SUBSTANCE P LEVELS IN SYNOVIAL FLUID AND PLASMA OF HORSES WITH OSTEOARTHRITIS.
Abstract: NOT REPORTED
Tufts University-200 Westboro Rd.- North Grafton, MA 01536
Veterinary School
Morris, E.
THE EFFECT OF SODIUM HYALURONATE ON CARTILAGE METABOLISM.
Abstract: NOT REPORTED
Tufts University-200 Westboro Rd.- North Grafton, MA 01536
Veterinary School
Seeherman, H. J.
APPLICATION OF A STANDARDIZED MUSCULOSKELETAL AND METABOLIC STRESS TEST TO THE EQUINE ATHLETE.
Abstract: Standardized clinical test have been developed and put into use to evaluate fitness and respiratory related abnormalities in performance horses. Reports appeared in EVJ over the past two years. Work in program includes comparisons between thoroughbreds and standardbred race horses.
Tuskegee, University of - Tuskegee, AL 36088
School of Veterinary Medicine
Gutierrez, A.
THERMOGRAPHIC EVALUATION OF PRAZOSIN IN LAMINITIC HORSES.
Abstract: This project involves the use of a vasodilator "PRAZOSIN" and its evaluation through pharmacokinetics, thermography and arterial blood pressure and its effect in laminitic horses.
Virginia Tech - Blacksburg, VA 24061
Marion duPont Scott Equine Medical Center
Sullins, K. E.
HEALING OF SUBCHONDRAL BONE CYSTS AND ARTICULAR DEFECTS IN THE HORSE: TREATMENT OF CLINICAL CASES.
Abstract: The objective of the recently completed research was to document the result of form-fitted sternal cancellous bone grafts placed into created defects in the medial femoral condyles of horses. The intent was to apply such grafts in treatment of clinical subchondral cysts. The final objective of this study is to dtermine the best procedures to be applied clinically.
Virginia Tech - Blacksburg, VA 24061-0442
VA-MD Regional College of Vet Med
Pleasant, S.
MEPIVACAINE HYDROCHLORIDE INTRA-ARTICULAR ANESTHESIA: INVESTIGATION OF TIMES TO ONSET, MAXIMUM ANESTHESIA, AND DURATION OF ACTION.
Abstract: Times to onset, maximum anesthesia and duration of action of mepivacaine hydrochloride intra-articular anesthesia will be evaluated in 8 horses. A chemical synovitis will be induced in each horse by injecting 10 mg of amphotericin-B into either the left or right intercarpal joint. The effect of intra-articular anesthesia of their intercarpal joint on relief of associated lameness will be evaluated at 5, 15, 30 and 60 minutes post-anesthetic administration.
Virginia-Maryland Regional college of Vet Medicine Marion duPont Scott Equine Med Cntr, Leesburg, VA 22075
Spurlock, G.; Spurlock, S.; Parker, G.
ULTRASONOGRAPHIC AND HISTOLOGICAL EVALUATION OF TENDONITIS: EFFECT OF HYALURONIC ACID THERAPY.
Abstract: Tendonitis was induced in the superficial digital flexor tendon of both forelimbs using a bacterial collagenase. The tendons were evaluated by clinical examination, ultrasonographic, and histologic evaluation. One tendon was treated with peritendinous injection of 20 to 60 mg of high molecular weight hyaluronic acid and the other received a balanced electrolyte injection peritendinously. The examinations were performed by blinded observers. The ultrasound & histologic exams were consistent with an increase in collagen.
Virginia-Maryland Regional College of Veterinary Medicine Blacksburg, VA 24061-0442
Marion duPont Scott Equine Med Center-Leesburg, VA
Fregin, F.; Donaldson, L.
EQUINE VASCULAR RESPONSES.
Abstract: Pulmonary, mesenteric and digital vascular contractile behavior and the response of these vascular regions to a variety of insults are integral to a number os disease processes that claim the lives or reduce the performance capacity of horses. With the ultimate goal of reducing the incidence of exercise induced pulmonary hemorrhage, exercise and anesthesia related hypoxemia, some forms of colic and laminitis, a long range project will be developed to identify the normal vasoactive behavior of these vascular beds and subsequently to study
Virginia-Maryland Regional College of Veterinary Medicine Blacksburg, VA 24061-0442
Marion duPont Scott Equine Med Center-Leesburg, VA
White, N.; Furr, M.; Robertson, J.
EVALUATION OF COSEQUIN IN INDUCED ARTHRITIC DISEASE IN HORSES: A PILOT STUDY.
Abstract: This study is designed to determine: 1) The lameness and joint pathology caused by an osteochondral defect and intra-articular cartilage particles. 2) The effect of chronic Cosequin ingestion on cartilage particle in induced arthritic disease of the equine fetlock joint compared to untreated horses.
Virginia-Maryland Regional College of Veterinary Medicine Blacksburg, VA 24061-0442
VMRCVM
Wilcke, J.; Crisman, M.; Pleasant, S.
INVESTIGATIONS OF THE ROLE OF MICROVASCULAR ENDOTHELIUM IN THE PATHOGENESIS OF LAMINITIS.
Abstract: Paired microvascular endothelium cultures derived from the omentum (EMVE-O) and the laminar coruim (EMVE-L) of six horses will be used to evaluate the production of the vasoconstrictors thromboxane A2(TxA2) and endothelin-1 (ET-1) and the vasodilators prostacyclin (PGI2), prostaglandin e2(PGE2), and endothelium derived relaxing factor (EDRF) in response to specific stimulants. The results of this study will be used to determine whether in-vitro models of laminitis should utilize EMVE-L or the more easily obtained EMVE-O lines.
Washington State University - Pullman WA 99164-6520
Dept. of VCAPP
Balch, O.
THE EFFECTS OF ALTERATIONS IN HOOF ANGLE AND MEDIOLATERAL HOOF BALANCE ON LOCOMOTOR FORCES EXERTED BY HORSES.
Abstract: The long-term goal of this research on equine locomotion is to identify and reduce the incidence of lameness in horses due to inappropriate hoof balance. The relationship between the presence of lameness and premature retirement from active competition is well documented. Inappropriate hoof angle and mediolateral hoof imbalance are major contributing factors in the development of lameness and frequently are the result of efforts to improve performance.
Washington State University - Pullman, WA 99164
College of Veterinary Medicine
Rathgeber-Lawrence, R.
THE INTERRELATIONSHIPS BETWEEN BONE STRAIN AND THE AMOUNT AND DISTRIBUTION OF LOCOMOTOR FORCES.
Abstract: This pilot study examines the interrelationships between the amount and direction of principal strain in the third metacarpal bone and the amount and distribution of locomotor forces exerted by horses exercising on a tread- mill. Correlations are made between the distribution of strain in the bone and the distribution of force across the hoof.
Washington State University - Pullman, WA 99164
Veterinary and Comparative Anatomy, Pharmacol. & Physiol.
Rice, N.; Ratzlaff, M. H.
EVALUATION OF LOCOMOTOR FORCES EXERTED BY JUMPING HORSES.
Abstract: The purpose of this study is to determine the vertical components of the take off and landing forces exerted by horses jumping over fences. This study will begin to accumulate normal values for the forces exerted by a horse jumping a fence of constant height and width and to determine how these forces change as the height and width of the jumps are varied.
Washington State University - Pullman, WA 99164
Veterinary and Comparative Anatomy, Pharmacol., & Physiol.
Ratzlaff, M.H.; Grant, B. D.
NEW HORSESHOE EFFECTS ON EQUINE LOCOMOTION.
Abstract: This is a limited study on the effects of a new horseshoe upon the locomotor forces and biomechanics of galloping horses.
Washington State University - Pullman, WA 99164
Veterinary and Comparative Anatomy, Pharmacology & Physiology
Ratzlaff; Grant; Miller; Frame; Kimbrell
THE EFFECT OF TRACK SURFACES ON HOOF IMPACT FORCES.
Abstract: This study is designed to provide quantitative information on the forces exerted by running horses. The understanding of the relationship of lameness to track surface is the ultimate aim.
Washington State University - Pullman, WA 99164
Veterinary Clinical Medicine and Surgery
Krpan, M.; White, K.; Grant, B; Sande, R; Gallina, A.; Newbry, J.
DEVELOPMENT AND EVALUATION OF A MODIFICATION OF THE TRANSPHYSEAL BRIDGING TECHNIQUE AS A MEANS OF INFLUENCING BONE GROWTH AT THE DISTAL METACARPAL PHYSIS.
Abstract: The project involved the use of a modification of the transphyseal bridging technique for angular limb deformities to recreate the rotational deformity of the fetlock and digit that accompanies carpal region angular deformities. The technique may be applicable to the clinical case of angular limb deformity arising in the carpal region which has an accompanying rotational deformity of the fetlock and digit by surgically de-rotating the digit to the normal stance.
Washington State University - Pullman, WA 99164-6520
College of Vet Medicine - Dept. of Vet & Comparative Anatomy, Pharmacology & Physiology
Ratzlaff, Marc H.
THE INTERRELATIONSHIPS BETWEEN LOCOMOTOR FORCES EXERTED BY HORSES AND THE PHYSICAL PROPERTIES OF TRACK SURFACES.
Abstract: The long term goal of this research on equine locomotion is to reduce the incidence of track-related lameness. These studies propose to address the relationships of the physical properties of track surfaces, the distribution of locomotor forces and the effects of these changes upon the stride of the horse.
Washington State University-Pullman, WA 99164
Veterinary Anatomy
Ratzlaff, M.H.
QUANTITATIVE EVALUATION OF JOINT MOTION AND FORCES OF FAST MOVING HORSES.
Abstract: To examine forces acting on the legs and the movements of the joints of the front and rear legs of horses moving at the gallop to provide information on the effects of different tracks, on normal locomotion of the horse. Additional studies will examine the effects of different lamenesses on locomotion as well as the effects of different tracks on the movement of lame horses.
Washington State University-Pullman, WA 99164
Veterinary Clinical Medicine
Grant, B.
WOBBLER SURGERY ON THE RACE HORSE SECRET INTENT.
Abstract: To investigate inheritability aspect of wobbler syndrome.
Washington State University, Pullman, WA. 99164
Veterinary Clinical Medicine and Surgery
Crawley, G. R.; Grant, B. D.; White, K.K.; Barbee, D. D.; Gallina, A.M.; Ratzlaff, M. H.
THE DEVELOPMENT AND EVALUATION OF A MODIFIED CLOWARD'S TECHNIQUE FOR THE ARTHRODESIS OF THE METACARPOPHALANAGEAL JOINT IN THE HORSE.
Abstract: The purpose of this project is to develop and evaluate a method of fetlock joint arthrodesis using a modification of the Cloward technique. If the technique is successful, it may be used on clinical cases of osteoarthritis, traumatic rupture of the suspensory ligament, severe sesamoid fractures, luxations of the fetlock joint and combinations of the above that usually necessitate the destruction of the horse.
Wisconsin-Madison, University of-Madison, WI 53706
School of Veterinary Medicine
Markel, M. D.
QUANTITATIVE EVALUATION OF THE REMODELING RESPONSE OF THE PROXIMAL SESAMOID BONE IN RACING THOROUGHBREDS TO RACING STIMULI.
Abstract: This three year study is designed to determine cranio-caudal bending rigidity, medio-lateral bending rigidity, axial compressive rigidity, torsional rigidity, maximum torque, angular deformation at failure, and energy absorption at failure of the humerus, femur, radius, tibia, third metacarpal bone (MCIII), and third metatarsal bone (MTIII) in the horse. The low cycle fatigue properties of these bones will also be measured.
Wisconsin-Madison, University of-Madison, WI 53706
School of Veterinary Medicine
Wilson, D. G.
TREATMENT OF EQUINE CANKER.
Abstract: Initially canker was treated with topical and systemic chloranphenicol. Since 1984 topical metronidazole has been used successfully when combined with minimal debridement.
Wisconsin, University of - Madison, WI 53706
School of Vet Med - Dept. of Surgical Sciences
Markel, Mark D.
STRUCTURAL AND LOCAL MATERIAL PROPERTIES OF EQUINE LONG BONES.
Abstract: Current techniques for repairing fractures of long bones in horses have limited success. Before we can effectively design new, more successful methods of fracture fixation, it is necessary to fully understand the overall structural and local material properties of horse long bones.The goals of this research are to comprehensively examine structural properties through use of radiography, quantitative computed tomography (QCT), and biomechanical testing and to examine material properties through measurement of the local indentation
Wisconsin, University of - Madison, WI 53706
School of Veterinary Medicine
Wilson, D. G.
ARTHRODESIS OF THE PROXIMAL INTERPHALANGEAL JOINT IN THE HORSE: A BIOMECHANICAL COMPARISON OF 4.5 MM AND 5.5 MM CORTICAL SCREWS.
Abstract: Using cadaver limbs and the parallel screw technique, three 4.5 mm cortical screws will be compared to two 5.5 cortical screws. The contruct will be tested in dorsal to palmar/plantar bending.
Wisconsin, University of - Madison, WI 53706
School of Veterinary Medicine
Wilson, D.G.; Klohnen, A.; Hendrickson, D.A.; MacWilliams, P.S.; Cooley, A.J.
AN EVALUATION OF THE EFFECTS OF 0.0005% CHLORHEXIDINE edta-tRIS ON THE TARSOCRURAL JOINTS OF PONIES.
Abstract: In preliminary in vitro project, EDTA-Tris was used to enhance the antibacterial effects of chlorhexidine. At a concentration of 0.0005%, chlorhexidine EDTA-Tris was uniformly lethal to clinical isolates of Staphylococuss aureus, E coli, and Streptococuss zooepidemicus. That concentration of chlorhexidine EDTA-Tris was used to lavage the tarsocrural joints of ponies. Project is completed and 0.0005% chlorhexidine EDTA-Tris did not adversely affect the tarsocrural joint of ponies. The solution is now being
Wisconsin, University of - Madison, WI 53706
School of Veterinary Medicine
Wilson, D.G.; Lopez, M.J.; Markel, M.D.
PROPERTIES OF A THIRD METACARPAL INTERLOCKING NAIL SYSTEM.
Abstract: The comparative biomechanical properties of a 13 mm interlocking nail and a two plate fixation will be evaluated in an unstable fracture model comprised of cadaver third metacarpii.
Wisconsin, University of - Madison, WI 53706
School of Veterinary Medicine - Dept. Surgical Sciences
Markel, M.D.; Hanson, P.D.
DEVELOPMENT OF A CABLE GRIP SYSTEM FOR ULNAR FRACTURE REPAIR IN HORSES.
Abstract: The goal of this study is to design a cable grip system for the repair of equine ulnar fractures. Advantages of such a system include greater handling ability with cables over monofilament wires, rigidity similar to plating techniques, better conformation to the narrow caudal ulna, reduced surgical time, reduced surgical exposure, and less instrumentation. Following the design of an equine cable grip system, mechanical testing of osteotomized ulnae (intact radii) repaired with either cable grip system or dynamic (more)
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